Here is the early pick from the Worldwide Leader.
It will be the defending national champions against the defending Heisman Trophy winner when No. 3 Clemson takes on No. 14 Louisville Saturday night.
The Cardinals almost knocked off the Tigers in Death Valley last year and they will have a chance to get revenge at home next weekend.
Who does ESPN like in the game? According to the FPI, Clemson is the heavy favorite.
Clemson is a 3-point road favorite according to OddsShark.
The Tigers and Cardinals will kick off at 8 p.m. ET on ABC.