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Duke vs. Louisville Prediction, Preview, Game Time, Channel

Looking for a Duke vs. Louisville prediction and preview? Stick around. We’ve got all of the pre-game analysis before the pivotal ACC matchup.

Friday, October 14, the Duke Blue Devils (3-3) take on the No. 7 Louisville Cardinals (4-1). The game will be played at Papa John's Cardinal Stadium in Louisville, KY. Read on for our Duke vs. Louisville prediction and preview.

According to ESPN’s matchup predictor, which is based on its Football Power Index, Louisville has a 97.7-percent chance to win this match-up. The spread also suggests that the Cardinals are heavy favorites to win the contest.

Spread: Louisville -32

Game Time: 7:00 p.m. ET

Channel: ESPN

Duke vs. Louisville preview:

The Blue Devils are coming off a 13-6 win over Army this past Saturday and will be looking to keep it rolling against a tough Louisville squad. If they want to have any chance at winning, they'll have to force turnovers like they did against Army, where they forced three. Unfortunately, they have a tendency themselves to give the ball away, as they did six times against Virginia in a home loss. Hard to say which Duke team will show up Friday.

Louisville is coming off a bye week after a tough loss to Clemson the week prior, and the Cardinals will be looking to make a statement that they still belong in the College Football Playoff with a lopsided win. The offense is still the best in the nation, and with the electric Lamar Jackson at the helm, things could get ugly fast for Duke.

Louisville and Duke have played once, in 2002, with the Cardinals beating the Blue Devils, 40-3.

Duke vs. Louisville prediction:

If I'm a Duke fan, I'm not watching this game. The Louisville Cardinals just spent their bye week pissed off and brooding over their loss to Clemson the week before, and you can bet the Cardinals are going to take out their frustration on the hapless Blue Devils. It's a blowout, and a score of 55 for the Cardinals might be conservative. Lamar Jackson continues his Heisman Trophy campaign, and Louisville continues to steamroll through the rest of the ACC.

Louisville 55, Duke 17