Despite heading into halftime with a four-point lead over Michigan State, Iowa stumbled in the second half and had its five-game winning streak snapped on its home court.
Tyler Cook and Luka Garza showed up on Thursday, but the Jordan Bohannon and Joe Wieskamp combined for just eight points against the Spartans.
On the other hand, the Spartans received contributions from eight different players in a hostile environment.
Now, the Hawkeyes will look to rebound from their disappointing loss this weekend when they travel to take on Minnesota.
The Golden Gophers nearly defeated No. 5 Michigan in Ann Arbor this week, but ultimately fell short at the buzzer. Jordan Murphy and Amir Coffey have done an excellent job of anchoring Richard Pitino's offense throughout the season.
With both teams desperately needing a win to remain toward the top half of the conference standings, expect Iowa and Minnesota to come out of the gates firing on all cylinders.
Minnesota has lost only one game at home this season, meanwhile Iowa has struggled on the road against Big Ten opponents.
Tipoff is set for 5 p.m. ET from Williams Arena on Sunday.
FS1 will broadcast the action with Rich Waltz and Bob Wenzel on the call.