The fifth week of the 2018 college football season is highlighted by two primetime matchups between top 10 squads.
Penn State is hosting Ohio State in State College, Pa. and Notre Dame is hosting Stanford in South Bend, Ind.
However, there will surely be some upsets.
There were several upsets during Week 4. Will that be the case in Week 5? Probably.
One major upset is being predicted by a couple of ESPN analysts in this week's top picks.
Two ESPN analysts, Ivan Maisel and Mitch Sherman, are picking No. 12 West Virginia to go down this weekend.
West Virginia, the No. 12 team in the country, is set to travel to Lubbock, Texas to take on Kliff Kingsbury's Red Raiders. It should be a good one.
Kickoff for that game is set for 12 p.m. E.T. on ESPN2.
You can view ESPN's full picks here.