Iowa State vs. Oklahoma is the first Big 12 game for both teams. Oklahoma looks very strong at 2-0, while Iowa State is coming off of a loss to rival Iowa.
The Sooners haven't missed a beat from last season, so far. Kyler Murray is playing himself into the Heisman conversation.
Unfortunately, during OU's win over UCLA, star running back Rodney Anderson went down with a knee injury and is out for the season, so Murray has even more on his shoulders now.
ISU is coming off of a breakout 8-5 season under Matt Campbell, and has pretty high expectations for the season.
ESPN’s FPI prediction for Iowa State vs. Oklahoma is out.
As you’d expect, Oklahoma is a heavy favorite against the Cyclones. FPI gives the Sooners an 85.2-percent chance to win.
Iowa State vs. Oklahoma will kick off at 12 p.m. ET on Saturday from Jack Trice Stadium in Ames, Iowa.
ABC will broadcast the contest.