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Ole Miss vs. LSU Prediction, Preview, Spread, Channel

Looking for a Ole Miss vs. LSU preview? Stick around. We’ve got all of the pre-game analysis before the SEC West matchup.

Saturday, Oct. 22, the Ole Miss Rebels play visitor to the LSU Tigers in the 105th meeting between the two schools. The game, to be played at Tiger Stadium, is slated for a 9:00 p.m. ET start time and will be broadcast on ESPN. Read on for our Ole Miss vs. LSU preview.

According to ESPN’s matchup predictor, which is based on its Football Power Index, LSU wins the matchup between the two teams 65.8% of the time. The spread, via Oddshark, has LSU favored as well.

Spread: LSU -4.5

Game Time: 9:00 p.m. ET

Channel: ESPN

Ole Miss vs. LSU preview:

Ole Miss enters the contest after falling in a heartbreaker to Arkansas last week, 34-30. It was Chad Kelly's worst game of the season in terms of passing as he went just 18-for-39 through the air for 253 yards to go along with one touchdown and one interception. He had 14 carries for 89 yards and two touchdowns as well.

The Rebels could not slow down the Arkansas rushing attack as the Hogs ran for 200 yards.

LSU is fresh off of a 45-10 win over Southern Miss where it racked up 459 yards of total offense.

Danny Etling completed just 11 passes on the day, but those 11 passes went for 276 yards and three touchdowns. Leonard Fournette did not play for the Tigers but is expected to play against the Rebels. Derrius Guice rushed for 162 yards on 16 carries for LSU in its win over Southern Miss.

The Rebels enter the game averaging 476 yards per game while LSU is averaging 409 per contest.

LSU leads the all-time series against Ole Miss with a 59-41-4 record, but Ole Miss has won two of the last three meetings including last year's contest, 38-17. Ed Orgeron, interim head coach of the Tigers, went 10-25 in his three years as Ole Miss' head coach from 2005-2007.

Ole Miss vs. LSU prediction:

It's impossible to know how Ole Miss will respond this week after a tough loss to Arkansas last weekend. Ole Miss responded nicely after its loss to Alabama earlier in the year by beating Georgia the next week, and it will do the same this week in Baton Rouge.

This has bad news written all over it for the Rebels with Orgeron on the sideline and Fournette expected to return, but Kelly won't have a bad game through the air two weeks in a row. Ole Miss makes it two straight against the Bayou Bengals.

Ole Miss 45, LSU 35