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ESPN Releases New Final 4 Prediction After North Carolina's Loss

oregon and unc in the final four

GLENDALE, AZ - APRIL 01: A general view as the North Carolina Tar Heels take on the Oregon Ducks during the 2017 NCAA Men's Final Four Semifinal at University of Phoenix Stadium on April 1, 2017 in Glendale, Arizona. (Photo by Christian Petersen/Getty Images)

We have our first major upset of the 2019 NCAA Tournament, as a No. 1 seed has fallen in the Sweet 16, with No. 1 North Carolina's blowout loss to No. 5 Auburn.

The Tar Heels were shellacked by the Tigers, as Bruce Pearl's team took a commanding lead early in the second half and never gave it up.

ESPN's Basketball Power Index has updated its predictions following the game.

Here's ESPN's latest Final Four prediction:

East Region: No. 1 Duke (46.6 percent)

Next best chance: No. 2 Michigan State (38.3)

coach k looks onto the court during the game against ucf

COLUMBIA, SOUTH CAROLINA - MARCH 22: Head coach Mike Krzyzewski of the Duke Blue Devils looks on against the North Dakota State Bison in the first half during the first round of the 2019 NCAA Men's Basketball Tournament at Colonial Life Arena on March 22, 2019 in Columbia, South Carolina. (Photo by Kevin C. Cox/Getty Images)

West Region: No. 1 Gonzaga (73.5 percent)

Duke and Gonzaga players lining up for a free throw attempt.

LAHAINA, HI - NOVEMBER 21: Javin DeLaurier #12 of the Duke Blue Devils lines up between Jeremy Jones #22 and Rui Hachimura #21 of the Gonzaga Bulldogs during a free-throw attempt during the first half of the game at the Lahaina Civic Center on November 21, 2018 in Lahaina, Hawaii. (Photo by Darryl Oumi/Getty Images)

South Region: No. 1 Virginia (75.4 percent)

tony bennett looks onto the court during ncaa tournament

COLUMBIA, SOUTH CAROLINA - MARCH 22: Head coach Tony Bennett of the Virginia Cavaliers looks on in the first half against the Gardner Webb Runnin Bulldogs during the first round of the 2019 NCAA Men's Basketball Tournament at Colonial Life Arena on March 22, 2019 in Columbia, South Carolina. (Photo by Streeter Lecka/Getty Images)

Midwest Region: No. 5 Auburn (55 percent)

Next best: Kentucky (32.8 percent)

Auburn takes on North Carolina.

KANSAS CITY, MISSOURI - MARCH 29: Seventh Woods #0 of the North Carolina Tar Heels handles the ball against Anfernee McLemore #24 of the Auburn Tigers during the 2019 NCAA Basketball Tournament Midwest Regional at Sprint Center on March 29, 2019 in Kansas City, Missouri. (Photo by Jamie Squire/Getty Images)

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There are two Sweet 16 games left tonight, with Duke taking on Virginia Tech and Kentucky playing Houston.