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Deon Cain's Knee Injury May Be "Season Ending"

Clemson Quarterback Kelly Bryant #2, wide receiver Deon Cain #8, and tight end D.J. Greenlee #87 of the Clemson Tigers celebrate following Bryant's touchdown.

CLEMSON, SC - SEPTEMBER 09: Quarterback Kelly Bryant #2, wide receiver Deon Cain #8, and tight end D.J. Greenlee #87 of the Clemson Tigers celebrate following Bryant's touchdown to start the second half of play during the Tigers' game football game against the Auburn Tigers at Memorial Stadium on September 9, 2017 in Clemson, South Carolina. (Photo by Mike Comer/Getty Images)

Thursday night's preseason NFL contests gave fans a look at some of the rookies who will be dominating the league for years to come. Unfortunately, there were a number of serious injuries to some of those rookies.

It came out within the last hour that Washington Redskins running back Derrius Guice, a second-round pick, tore his ACL and will be out for the season. Now, another rookie with some potential might be in the same boat.

Michael Lombardi is reporting that Indianapolis Colts rookie Deon Cain, out of Clemson, injured his knee and may be out for the season.

Cain was a sixth-round pick, but he showed a lot of promise in camp. He was competing to be a starting wideout for the team.

Cain had one catch in the team's preseason game against Seattle before suffering the injury. Hopefully, Lombardi is wrong and he gets a better diagnosis than is being advertised. In his final year at Clemson, Cain had 58 catches for 734 yards with six touchdowns. He was one of the team's most consistent threats at wideout. We'll keep you updated on Cain's status moving forward. Update: Cain has a torn ACL and will miss his rookie season, per the Colts.

Unfortunate, to say the least.