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No. 4 Seed Arizona Loses In NCAA Tournament's Biggest Upset

Sean Miller with his hands clasped.

Day 1 of the 2018 NCAA Tournament is ending with a massive, massive upset.

Arizona, the No. 4 seed in the South Region (and one of the country's most-popular national title picks this year), has gone down.

The high-seeded Wildcats fell to No. 13 Buffalo. The game wasn't even close.

Final score: Buffalo 89, Arizona 68.

The Bulls dominated the action from the start and carried a lead into halftime. Buffalo consistently extended its lead as the second half went on.

Arizona has had several disappointing NCAA Tournament runs under Sean Miller. This might be the most-disappointing, though.

The Wildcats were listed as the 8th-most likely national champion in Las Vegas before the NCAA Tournament started. And they're out on Day 1.

The future of Arizona's program, both with this result and the allegations surrounding Sean Miller, is clearly very much in the air.

Buffalo, meanwhile, moves on to face No. 5 seed Kentucky in the second round. That game will be played on Saturday.

A tipoff time and TV channel are set to be released later.