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OddsShark Computer Predicting A Big NCAA Tournament Upset

Two basketballs ahead of the Final Four.

INDIANAPOLIS, IN - MARCH 29: A detail of NCAA Official Wilson basketballs are seen racked up on the court prior to Oregon playing against Louisville during the Midwest Region Semifinal round of the 2013 NCAA Men's Basketball Tournament at Lucas Oil Stadium on March 29, 2013 in Indianapolis, Indiana. (Photo by Andy Lyons/Getty Images)

The Sweet 16 gets back into action tonight. The first games of the evening are set to tip off in minutes.

This evening, we've got Kansas-Clemson, Villanova-West Virginia, Duke-Syracuse and Purdue-Texas Tech.

Are we going to get any upsets? We certainly got some last night.

Kentucky, the clear favorite in the South Region, and Gonzaga, a popular pick in the West Region, both lost.

Are any top seeds at risk this evening?

OddsShark's computer says yes.

The sportsbook is predicting one major upset: Clemson over Kansas.

Here's the score prediction:

OddsShark's score prediction for Clemson Kansas.

Clemson has certainly looked good so far this tournament.

The game is set to tip off at 7:07 p.m. E.T. on CBS.