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Week 5 Predictions: NFL Picks Against The Spread

It’s time to take a look at this week’s slate of games and make our week 5 NFL picks against the spread.

The week 5 NFL slate of games is a good one. Let’s take a look at some marquee matchups prior to our NFL picks against the spread.

While it's a matchup of a 3-1 team and an 0-4 team, the Patriots - Browns matchup highlights the 1:00 p.m. EST games as Tom Brady makes his first start of the season at quarterback.

The Texans make the trip to Minneapolis to take on the Vikings in a meeting between two 3-1 teams which is another big game set to kick off at 1:00 p.m. EST.

In the late afternoon, and arguably the best matchup of the day, the 4-0 Broncos host Matt Ryan and the 3-1 Falcons with kick off set for 3:05 p.m. EST.

Sunday Night Football features the Packers hosting the Giants while Monday Night Football will take us to Carolina as the Panthers host the Buccaneers.

We’ll now take a look at the odds are for each game, via Oddsshark, and make our NFL picks against the spread below.