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Bills vs. 49ers Prediction, Preview, Game Time, Channel

Bills vs. 49ers preview: Rob Ryan looks to keep momentum going with Chip Kelly's San Francisco squad coming to Buffalo.

On Sunday, October 6th, the Buffalo Bills play host to the San Francisco 49ers. The game, to be played at New Era Field in Buffalo, is slated for a 1:00 p.m. ET start time and will be broadcast on FOX. Read on for our Bills vs. 49ers preview.

According to ESPN’s matchup predictor, which is based on its Football Power Index, Buffalo has an 79.5-percent chance to win the game. The spread, via Oddsshark, has the Bills favored as well.

Spread: Bills -7.5

Game Time: 1:00 p.m. ET

Channel: FOX

Bills vs. 49ers preview:

The Bills are 3-2, with three straight wins after beating the Los Angeles Rams 30-19 on the road. The Niners are 1-4, and coming off of a 33-21 loss to the Arizona Cardinals.

Tyrod Taylor did not have his best game against the tough Rams defense, finishing with 152 total yards, and two passing touchdowns. LeSean McCoy had a big day on the ground, with 150 yards on 18 carries. Charles Clay caught five passes for 73 yards, and Marquise Goodwin had two receptions for 13 yards and a score.

After a 162 yard, one touchdown, two interception performance, Niners quarterback Blaine Gabbert is being benched for Colin Kaepernick. Carlos Hyde has been a bright spot for San Francisco, and ran for 78 yards and a touchdown against the Cardinals. Jeremy Kerley had a nice game as well, catching eight passes for 102 yards and a score.

The 49ers have a slight lead in the all-time series, 6-5. San Francisco blew out Buffalo in the last meeting between these two teams, 45-3 in 2012. The Bills last beat the Niners in 2004.

Bills vs. 49ers prediction:

The Bills are rolling while the 49ers are faltering, and have looked terrible since Week 1. With the game in Buffalo, and San Francisco making the dreaded West-to-East trip with an early start, the Bills should keep things going.

Bills 23, 49ers 10