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AP College Football Analyst Predicting Major Top 10 Upset This Weekend

A general view of the Los Angeles Memorial Coliseum.

LOS ANGELES - NOVEMBER 11: General view of action as the Oregon Ducks take on the USC Trojans on November 11, 2006 at the Los Angeles Memorial Coliseum in Los Angeles, California. The Trojans defeated the Ducks 35-10. (Photo by Christian Petersen/Getty Images)

We have seen a top 10 team lose each of the last three weekends. First it was Georgia, then Wisconsin and finally Oklahoma.

Will another major college football upset take place Saturday? Associated Press national writer Ralph Russo believes it will.

Russo unveiled his weekly picks column today. In it, he projects USC will knock off No. 7 Oregon at The Coliseum.

Trojans defense is riddled with injuries, but USC has yet to lose at home ... USC 34-31, UPSET SPECIAL.

The Trojans are 1-0 against top 10 teams this season, having beaten then-No. 9 Utah on Sept. 20. At 5-3, USC needs one more win to wrap up bowl eligibility.

Oregon, meanwhile, has not lost since they fell to Auburn in Week 1. The Ducks are the Pac 12's only College Football Playoff hope, so if they lose Saturday, the conference will be shut out of the playoff for the third-straight year.

You can view all of Russo's Week 10 picks right here. If you want to check out our staff picks at The Spun this week, click here.

Oregon and USC will kick off at 8 p.m. ET on FOX.