We have seen a top 10 team lose each of the last three weekends. First it was Georgia, then Wisconsin and finally Oklahoma.
Will another major college football upset take place Saturday? Associated Press national writer Ralph Russo believes it will.
Russo unveiled his weekly picks column today. In it, he projects USC will knock off No. 7 Oregon at The Coliseum.
Trojans defense is riddled with injuries, but USC has yet to lose at home ... USC 34-31, UPSET SPECIAL.
The Trojans are 1-0 against top 10 teams this season, having beaten then-No. 9 Utah on Sept. 20. At 5-3, USC needs one more win to wrap up bowl eligibility.
Oregon, meanwhile, has not lost since they fell to Auburn in Week 1. The Ducks are the Pac 12's only College Football Playoff hope, so if they lose Saturday, the conference will be shut out of the playoff for the third-straight year.
Oregon and USC will kick off at 8 p.m. ET on FOX.