Tagovailoa was diagnosed with fractured ribs, an injury he suffered in last week's loss to the Buffalo Bills. He's in "a lot of pain" according to head coach Brian Flores.
As a result, Jacoby Brissett will get the start at Allegiant Stadium. The veteran backup threw for 169 yards and an interception in relief of Tagovailoa in Week 2.
Tua's injury is a brutal turn of events for a Miami offense that has struggled through two weeks and a onetime No. 5 overall draft pick who has been bitten by injuries dating back to his college days.
It is fair to wonder what the rest of Tua's season--and possibly the rest of his time in Miami--will look like.
In the meantime, Brissett will look to lead the Dolphins to their second win of the season against a 2-0 Raider team.
Kickoff is set for 4:05 p.m. ET on Sunday.